多孔结构对碳酸化羟基磷灰石骨水泥溶解度的影响

The Effect of Pore Configuration on the Dissolution of the Carbonated Hydroxyapatite Cement.

目的探讨碳酸化羟基磷灰石骨水泥中多孔结构存在的意义及其对溶解性能的影响。方法合成能原位固化形成多孔结构的碳酸化羟基磷灰石骨水泥,并通过扫描电镜和模拟体液浸泡实验,观察其孔隙结构和失重率变化。结果多孔碳酸化羟基磷灰石骨水泥固化后的孔隙率为42%,平均孔径为153μm,孔之间以90μm左右的连通孔互相贯通,孔隙结构与松质骨相似。碳酸化羟基磷灰石的多孔结构增加了其比表面积,利于体液循环。经模拟体液浸泡后,其失重率的改变比普通型碳酸化羟基磷灰石骨水泥明显增加,二者差异显著。结论碳酸化羟基磷灰石骨水泥内部的多孔结构能促进其体外溶解。

Objective To investigate the significance of pore configuration and it＇s effect on the dissolution of carbonated hydroxyapatite cement. Method To prepare a porous carbonated hydroxyapatite cement, evaluate it＇s pore configurations with election microscope and examine it＇ s changes of weight losses according to the test of immersion in simulated body fluid. Result After setting in situ, the pore configurations of porous carbonated hydroxyapatite cement were similar to natural cancellous bone. The porosity was 42 % , the average of pore diameter was 153μm, and the pores were interconnected resulting in continuous pore structures in 90μm. The pore configurations increased the areas of carbonated hydroxyapatite cement which benefited to the circulation of body fluid. After the immersion in simulated body fluid, the weight losses of porous carbonated hydroxyapatite cement were more obvious than thoes of common carbonated hydroxyapatite cement. Conclusion The pore configurations played an important role in dissolution of carbonated hydroxyaptite cement in vitro.