摘要
以生物可降解材料乳酸乙醇酸共聚物为载体,采用复乳溶剂挥发法结合高压均质法制备5氟-尿嘧啶毫微粒,通过正交试验设计优化5氟-尿嘧啶毫微粒的制备工艺,用透射电镜观察毫微粒的形态,并对所制得毫微粒的平均粒径、载药量、包封率及重现性进行了研究。实验结果表明:优化制备工艺条件下所制得的5-氟尿嘧啶毫微粒为圆整的类球形实体粒子,平均粒径为85.4 nm,载药量为(12.4±0.7)%,包封率为(64.1±5.3)%,制备工艺简单,重现性好。
5-fluorouracil nanoparticles were obtained by alspoly ( L-lactic-co-glycolic acid) (PLGA). In order to W/O/W-liquid drying process using biodegradable materireach submicron size, a high pressure homogenizer to obtain nanoparticles with a high grade of monodispersity was used. The orthogonal test design was used to optimize the conditions of preparation. The shape of the nanoparticles was observed by TEM. The mean diameter and the particle size distribution of nanoparticles, the encapsulation efficiency, the drug loading, the reappearances of pharmaceu- tical technology were investigated. The results indicated that 5-fluorouracil PLGA nanoparticles were sphere like with the mean size of 85.4 nm, the drug loading was ( 12.4 ± 0. 7 ) %, the encapsulation efficiency of nanoparticles was (64. 1±5.3)%.
出处
《南京工业大学学报(自然科学版)》
CAS
2006年第4期52-56,共5页
Journal of Nanjing Tech University(Natural Science Edition)