帕病3号方治疗帕金森病30例临床研究

Clinical Study on Pabing Recipe Ⅲ for Treatment of 30 Cases of Parkinson's Disease

目的:观察帕病3号方对帕金森病(PD)的疗效。方法:60例寒热错杂、厥阴风动型PD患者随机分为试验组和对照组各30例。试验组采用帕病3号方加美多巴片治疗,对照组给予美多巴片加中药协定方治疗,两组疗程均为3个月。观察两组患者治疗前后帕金森病综合评分量表(UPDRS)积分及Hoehn-Yahr分级改善情况。结果:试验组患者精神、行为、情绪、日常活动及运动功能评分均较治疗前明显下降(P<0.05),对照组仅日常活动积分明显下降(P<0.05)。试验组总有效率为43.33%,明显高于对照组的16.67%(P<0.05)。结论:帕病3号方治疗寒热错杂、厥阴风动型PD具有较好的临床疗效。

Objective：To observe therapeutic effect of Pabing Recipe Ⅲ on Parkinson＇s disease （PD）. Methods：60 eases of PD with TCM syndrome type of intermingled heat and cold and type of Jueyin wind stirring were randomly divided into a test group and a control group, 30 eases in each. The test group were treated with Pabing Recipe Ⅲ plus Madopa Tablets and the control group with Madopa Tablets plus fixed prescription of Chinese herbs recipe. The treatment course of both groups was 3 months. Improvement of score for Unified Parkinsons Disease Rating Scales （UPDRS）and Hoehn-Yahr grading before and after treatment were compared. Results：The cumulative scores of behavior,mind,emotion,daily activity and motor function in the patients of the test group significantly decreased after treatment（P〈0. 05） ,and only the cumulative score for daily activity in the patients of the control group significantly decreased （P〈0. 05）. The total effective rate was 43.33% in the test group which was significantly higher than 16.67% in the control group（P〈0.05）. Conclusion ：Pabing Recipe Ⅲ has definite therapeutic effect on the patient of PD with TCM Syndrome type of intermingled heat and cold and type of Jueyin wind-stirring.