干燥综合征106例中医证候分类回顾性研究

Retrospective Study on Classification of TCM Syndromes of 106 Cases of Sjogren Syndrome

目的:探讨原发性干燥综合征(SS)中医证候学及病因病机的特点。方法:对106例SS患者进行回顾性调查和分析,将中医首诊时收集的临床资料进行证候分类,分别统计各证候类型与发病年龄、病程、临床症状、舌象、脉象及主要实验室指标的关系。结果:将SS分为阴虚内燥、气阴两虚、阴虚血瘀、阴虚湿热、气阴两虚血瘀、气阴两虚血瘀湿热6个证候类型。结论:SS以肝肾阴虚为主,累及肺脾气虚,兼夹瘀血、湿热为患。虚实夹杂为SS的证候学特点,阴虚津亏为本,气虚、阳虚为其所累,瘀、痹、燥为标,属本虚标实之证。

Objective：To explore characteristics of TCM syndrome,pathogenic factors and pathogenesis of primary sjogren syndrome（SS）. Methods：Retrospective investigation and analysis were carried out in 106 cases of SS. Syndromes of the collected clinical data in first visit were classified, and the relationship of all syndromes with attacking age, course of disease, clinical symptoms, tongue manifestation, pulse manifestation and main laboratory indexes were analyzed respectively. Results： SS were divided into 6 syndrome types, i. e. endogenous dryness due to yin deficiency, deficiency of both qi and yin, yin deficiency and blood stasis, yin deficiency and damp-heat,both qi and yin deficiency and blood stasis,both qi and yin deficiency and blood stasis and damp-heat. Conclusion： For SS, yin-deficiency of both the liver and kidney is the main type, with qi-deficiency of the lung and spleen, intermingled with blood stasis,damp-heat. Syndrome of intermingled deficiency with excess is the characteristic of SS syndrome subject. Yin-deficiency and depletion of fluid is the essence involving qi-deficiency and yang-deficiency, blood stasis,stagnation syndrome, dryness are the superficiality aspect of the syndrome, belonging to syndrome of deficiency in origin and excess in superficiality.