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骨形态发生蛋白在神经系统中的表达和功能研究进展

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摘要 近年来,骨形态发生蛋白(bone morphogenetic proteins,BMPs)在神经系统中的功能越来越受到人们的关注,现已发现,不同亚型的BMPs在神经系统中的不同区域呈持续性表达,一系列体外和体内动物实验证明BMPs不仅在神经系统发育过程中发挥重要作用,并且在成熟神经系统受到损伤时具有神经保护和神经再生功能,其确切机制有待通过实验进一步阐明。
作者 俞键 杨卓
机构地区 南开大学医学院
出处 《生理科学进展》 CAS CSCD 北大核心 2006年第3期279-281,共3页 Progress in Physiological Sciences
基金 国家自然科学基金资助课题(30370386 30470453)
关键词 骨形态发生蛋白 神经保护 神经再生
分类号 R741.02 [医药卫生—神经病学与精神病学]
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参考文献10

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  • 3管峰,杨利国,程瑞禾,曹少先.骨形态发生蛋白家族及其受体在生殖调控中的作用[J].生理科学进展,2004,35(3):262-264. 被引量：12
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  • 5Yabe T,Samuels I,Schwartz JP.Bone morphogenetic proteins BMP-6 and BMP-7 have differential effects on survival and neurite outgrowth of cerebellar granule cell neurons.J Neurosci Res,2002,15:161～168.
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二级参考文献8

  • 1Shimasaki S, Zachow RJ, Li D, et al. A functional bone morphogenetic protein system in the ovary. Proc Natl Acad Sci USA, 1999,96: 7282-7287.
  • 2Hoodless PA, Haerry T, Abdollah S, et al. MADRI, a MAD-related protein that functions in BMP-2 signaling pathways. Cell, 1996, 85: 489-500.
  • 3Souza CJH, Campbell BK, McNeilly AS, et al. Effect of bone morphogenetic protein 2 (BMP2) on oestradiol and inhibin A production by sheep granulose cells,and localization of BMP receptors in the ovary by immunohistochemistry. Reproduction, 2002,123: 363～
  • 4Souza C J, MacDougal C, Campbell BK, et al. The Booroola(FecB) phenotype is associated with a mutation in the bone morphogenetic receptor type 1B (BMPR-1B) gene. J Endocrinol, 2001,169: R1-6.
  • 5Montgomery GW, Galloway SM, Davis GH, et al. Genes controlling ovulation rate in sheep. Reproduction, 2001,121: 843-852.
  • 6Galloway SM, McNatty KP, Cambridge LM, et al. Mutations in an oocyte- derived growth differentiation factor gene(BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner. Nature Genetics, 2000, 25 : 279～283.
  • 7Mulsant P, Lecerf F, Fabre S, et al. Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Merino ewes. Proc Natl Acad Sci USA, 2001, 98: 5104-5109.
  • 8林海燕,王红梅,祝诚.转化生长因子-β信号传导的Smad通路[J].中国科学（C辑）,2003,33(2):97-109. 被引量：9

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生理科学进展
2006年 第3期

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