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质谱技术引领肿瘤早期诊断新时代 被引量:1

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摘要 当癌症处于中晚期后再采取治疗措施,所需治疗费用非常昂贵,且很难根治,而采用液体芯片——飞行时间质谱技术检测,只需要不到1000元。
作者 王霞
出处 《中国医院院长》 2006年第14期70-71,共2页 China Hospital CEO
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  • 1Leung SM,Mok SC. A new approach to profile ovarian cancer serum using functionalized magnetic beads, AnchorChipTM technology. MALDI TOF MS, MALDI-TOF/TOF MS and bioinformatics. Mol Cell Proteomics, 2003,2 : 31.
  • 2Leung SM, Mok SC. Quality management of ovarian cancer profiles using functionalizied magnetic beads, AnchorChip ( TM ) technology, MALDI-TOF MS and, MALDI-TOF/TOF MS. Proceedings of the American Association for Cancer Research Annual Meeting, 2004,45: 1205.
  • 3Villanueva J, Philip J, Entenberg D, et al. Serum peptide profiling by magnetic particle-assisted, automated sample processing and MALD1 TOF mass spectrometry. Anal Chem, 2004,76:1560-1570.
  • 4Cazares I.H, Mitchell Green Shamina, Leung SM, et al. Serum protein expression patterns in head and neck cancer for biomarker discovery and identification using MALDI-TOF/ TOF MS. Proceedings of the American Association for Cancer Research Annual Meeting, 2005,46 : 1132.
  • 5Freed GL. Cazares LH, Fichandler CE, et al. Differential capture of serum proteins for expression profiling and biomarker discovery in pre-and posttreatment head and neck cancer samples. Laryngoscope, 2008,118:61-68.
  • 6Leung SM,Sheldon M,Lau CC. A novel and rapid approaich to protein expression profiling of cerebrospinal fluid (CSF) from medulloblastoma patients using functionalizied magnetic beads, AnchorChip(TM) technology, MALDI-TOF and MALDI-TOF/TOF mass spectrometry. Neuro-Oneology, 2004,6:410.
  • 7Chang JT, Chen LC, Wei SY, et al. Increase diagnostic efficacy by combined use of fingerprint markers in mass spectrometryplasma peptidomes frora nasopharyngeal cancer patients for example. Clin Biochem, 2006,39 : 1144-1151.
  • 8Cheng AJ, Chen LC, Chien KY, et al. Oral cancer plasma tumor marker identified with bead-based affinity-fractionated proteomic technology. Clin Chem, 2005,51 : 2236-2244.
  • 9Villanueva J, Nazarian A,Lawlor K,et al. A sequence-specific exopeptidase activity test ( SSEAT ) for " functional " biomarker discovery. Mol Cell Proteomics, 2008,7 : 509-518.
  • 10Villanueva J, Shaffer DR, Philip J, et al. Differential exoprotease activities confer tumor-specific serum peptidome patterns. J Clin Invest, 2006,116 : 271-284.

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