胰岛素增敏剂对不同胰岛素水平的2型糖尿病的疗效观察

Observations on the effect of insulin sensitizer on patients with type 2 diabetic of different insulin levels

目的观察胰岛素增敏剂对不同胰岛素水平的2型糖尿病的疗效。方法对68例不同胰岛素水平的2型糖尿病的患者服用马来酸罗格列酮3个月后空腹、餐后2 h血糖和C肽值的变化进行观察对比,总结各组的疗效差别。结果治疗前后基础高分泌组和正常分泌组(分组标准详见文中)空腹、餐后血糖和C肽均有明显差异(P<0.05),在降低C肽方面基础高分泌-餐后高分泌组(H-H组)尤为明显(P<0.01)。在基础低分泌组的两组中空腹C肽均有下降(P<0.05),其中基础低分泌-餐后高分泌组(L-H组)以餐后血糖和C肽的降低较为突出(P<0.01),空腹血糖降低不明显。但在基础低分泌+餐后低分泌组L-L组中除空腹C肽有明显下降外(P<0.05),余均无明显变化。结论胰岛素增敏剂较适合于胰岛素分泌较高或正常的2型糖尿病患者,可通过增加胰岛素的敏感性而益于血糖的控制及降低高胰岛素血症。对低胰岛素分泌的糖尿病患者作用不显著。

Objective To investigate the effect of insulin sensitizer on patients with type 2 diabetic of different insulin levels. Methods Sixty - eight patients with type 2 diabetes of different insulin levels were given rosiglitazone maleate for 3 months. Fasting and 2 h postprandial plasma glucose and C pepdide were measured before and after treatment. Results Contrasted at pre - and post - treatment , the datas at post - treatment of the fasting or postprandial plasma glucose and C pepdide had a great difference than before in the group of hypersecretion and normal secretio（ P 〈 0. 01 ）. Fasting C pepdide decreased in both groups of baseline lower secretion group（ P 〈 0. 05 ） , of which the postprandial plasma glucose and C pepdide decreased more significantly in L- H group but fasting glucose did not decrease significantly. While in L- L group, there were no significant changes except the significant decrease in fasting C pepdide（ P 〈 0. 05 ）. Conclusion Insulin sensitizer is more suitable for patients with type 2 diabetes of higher or normal insulin secretion. It can increase the sensitivity to insulin, which is beneficial to the blood glucose control and decrease in hyperinsulinmia. But its effect on diabetic patients with lower insulin secretion is not obviouse.