儿童神经母细胞瘤远隔器官转移的影像学检测

The best imaging modality for evaluating the distant metastasis of neuroblastoma in children

目的探讨儿童神经母细胞瘤远隔器官转移的CT影像特征及其诊断应用价值。方法收集我院4年来有病理组织学诊断的神经母细胞瘤住院病例30例神经母细胞瘤的螺旋CT影像资料,均经手术病理活检,骨髓穿刺活检,或尿中儿茶酚胺代谢产物检测确诊,按照年龄分布和累及器官部位分类,描述发生部位影像特征,进行回顾性研究。结果神经母细胞瘤远隔器官转移通常发生在年龄早,高临床分期,原发灶可以不显著的情况下,3岁以下占远处转移总数的78.57%。结论具有早期转移倾向之神经母细胞瘤远隔器官转移征象较原发肿瘤更明显,螺旋CT是判定病灶性质,评估预后的重要临床手段。

Objective To investigate the characteristics and diagnostic value of spiral CT imaging to the distant metastasis of the neuroblastoma, Methods All the cases of neuroblastoma （ n = 30） with spiral CT examined during 4 years＇ period were reviewed. The diagnoses were confinned by histopathological examination of surgically removed example, marrow biopsy or the V. M, A determination in the urine, Imaging data of neuroblastoma were analysed according to the age of the children and the involved organ, Results The distant metastasis of neuroblastoma usually occurred in young children, high clinical stages and in situations where primary tumors may be not evident. Conclusion Neuroblastoma have a tendency to metastasize early, the signs of distant metastasis can be more evident than those of primary tumors. Spiral CT appears to be the important clinical tool for detecting the metastatic lesion and assessing the prognosis of the patients with distant metastasis.