氯沙坦治疗老年人单纯收缩期高血压临床研究

Losartan in Treatment of Older Patient with Isolated Systolic Hypertension

目的研究氯沙坦对老年人收缩期高血压的临床作用。方法对比82例老年单纯性收缩期高血压患者应用氯沙坦治疗前及治疗2周、4周、8周后的血压及心率变化;治疗前后血浆内血管紧张素Ⅱ(AngⅡ)、醛固酮、内皮素的变化;治疗前后血、尿常规、肝肾功能、血脂、血糖、电解质、心电图变化。结果降压总有效率为86.5%。治疗后AngⅡ显著增高(P<0.01),醛固酮、内皮素显著降低(P<0.05)。血、尿常规、肝肾功、血脂、血糖、电解质及心电图均无明显变化。不良反应发生率低。结论氯沙坦治疗老年人收缩期高血压疗效好,降压作用持续稳定,耐受性良好,不良反应轻微。

Objective To investigate the efficacy of losartan in the treatment of older patient with isolated systolic hypertension. Methods The variation of the blood pressure and heart rate of 82 cases treated with losartan before and after therapy 2weeks,4weeks, and 8weeks was detected respectively. Angiotensin Ⅱ （ Ang Ⅱ ）, aldosterone （ Aid）, and endothelin, blood, urine, hepatic and renal function,blood glucose,electrolyte and ECG were examined before and after therapy. Results The total effective rate was 86. 5 %. Ang Ⅱ increased （ P 〈 0. 01 ）. while Aid and ET decreased （ P 〈 0. 05 ） after the therapy. Blood, urine, hepatic and renal function, blood glucose, electrolyte and ECG were found no significant difference. The adverse reactions of losartan were mild. Conclusion Losartan is a safe and reliable antihypertensive agent which lowers blood pressure persistently and smoothly.