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基质金属蛋白酶-2在胃癌中的表达及意义 被引量：3

Expression and significance of matrix metalloproteinase-2 in gastric carcinoma
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摘要 目的研究基质金属蛋白酶2(MMP2)在胃癌中的表达与胃癌侵袭转移的关系。方法采用免疫组化SP法检测60例胃癌组织,20例正常胃组织中MMP2的表达。结果胃癌组织中MMP2的阳性表达率为66.7%,淋巴转移组与无转移组之间差异有统计学意义(P<0.05),MMP2的表达与胃癌的病理相关(P<0.05)。结论MMP2在胃癌生长、侵袭和转移过程中起着重要的作用,可作为反映胃癌的生物学行为的一个参考指标。 Objective To investigate the relationship between the expression of matrix metalloproteinase-2 （MMP-2） and invasion or metastasis of gastric carcinoma. Methods lmmunohistochemistry was used to detect the expression of MMP-2 in 60 cases of gastric carcinoma tissues and 20 cas~ of normal tissues. Results The positive expression rare of MMP-2 in gastric carcinoma was 66.7 %. The expression of the MMP-2 was much higher in tumor tissue with positive-node than with negative-node, and was significantly corrected with pathological stage. Conclusion MMP-2 plays a key role in invasions and metastasis of gastric carcinoma,and MMP-2 might be a valuable market in reflecting its behavior of gastric carcinoma.
作者 陈吉彩 陈必成 陈晓曦 余震 朱冠保 龚建平
机构地区 温州医学院第一附属医院胃肠外科 温州医学院第一附属医院外科实验室 华中科技大学同济医学院胃肠外科
出处 《中国基层医药》 CAS 2006年第6期906-907,共2页 Chinese Journal of Primary Medicine and Pharmacy
关键词 胃肿瘤 基质金属蛋白酶-2 免疫组织化学 Gastric neoplasma Matrix metalloproteinase-2 Immunohistochemistry
分类号 R735.2 [医药卫生—肿瘤]
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中国基层医药
2006年 第6期

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