斯普林与泼尼松对特发性血小板减少性紫癜的细胞免疫作用

The research of immunologic function change by using sipulin and prednisone to treat 48 cases of idiopathic purpura haemorrhagica

目的观察斯普林与泼尼松对特发性血小板减少性紫癜的细胞免疫功能的改变。方法随机分为两组,斯普林与泼尼松为治疗组48例,单用泼尼松对照组45例,采用流式细胞仪分别测定两组患者用药前后T细胞亚群及NK细胞活性的变化。结果治疗组治疗后患者CD8阳性百分率明显低于对照组、CD+4/CD+8值显著高于对照组(P<0.05),NK细胞活性百分率略高于对照组(P>0.05)。结论斯普林可有效地改善特发性血小板减少性紫癜的免疫功能。

Objective To observe immunologic function change by using sipulin and prednisone to treat 48 cases of idiopathic purpura haemorrhagica. Methods 93 cases with ITP were divided into two groups randomly. 48 cases of sipulin and prednisone treatment group and 45 cases of prednisone treatment contrast group,adopt flow cy- tometer to measure the change of T cell subpopulation and NK cytoactive before and after the medicine using of the patients of two groups respectively. Results After treatment, the CD8 positive percent of patients of sipulin and prednisone treatment group was distinctly lower than the contrast group, CD4＋/CD8^＋ value was remarkably higher than the contrast group （ P 〈 0.05）, NK cytoactive percent was a little bit higher than the contrast group （ P 〉 0.05）. Conclusion Sipulin can improve the immunologic function of patients of purpura haemorrhagica.