皮肌炎与多发性肌炎的肺间质病变临床分析

Study on interstitial lung disease resulting from dermatomyositis or polymyodsitis

目的研究皮肌炎(DM)和多发性肌炎(PM)合并肺间质病变(ILD)患者的临床及血清学特点以及影响预后的相关因素,为临床提供借鉴。方法DM/PM患者42例按合并ILD18例与未合并ILD24例的临床症状及血清学检查进行比较。结果DM/PM合并ILD的发生率42.9%,合并ILD患者血清Jo1抗体阳性率、LDH和AST水平高于未合并ILD患者,有雷诺现象ILD患者预后不良。结论DM/PM合并ILD发生率高,对所有DM/PM患者均应进行HRCT检查,尽早对DM/PM合并ILD作出诊断。

Objective To investigate the clinical and serological manifestations of the interstitial lung disease （ILD） resulting from the dermatomyositis（DM） or the polymyodsitis（ PM）, and the factors affecting the resulting of treatment for the purpose of providing necessary reference for clinical treatment and diagnosis. Methods The clinical manifestations and the findings of serological tests of 18 patients compared with only DM or PM. Results ILD was likely to strike 42.9 percent of patients with DM or PM ,who were higher than those without ILD in the rate of positive Jo-1, LDH and Reynolds disease. Conclusion The patients with DM or PM, with their high probability to be stricken by ILD,need HR-CT scanning in order to be diagnosed as early as possible.