葡萄糖酸锌对人体内环境锌铜水平影响的研究

The effects of zinc glucose on the level of Zinc and Copper in men

目的：探讨高锌摄入对血压、心率及人体内环境锌铜水平的影响。方法：选择饮食结构及饮食习惯相同的健康成人38例口服葡萄糖酸锌（50mg／d），连续8周，于服葡萄糖酸锌前、后4、8周及停锌后4周4次查体，同时取血、尿、发测定锌、铜含量。结果：服锌后收缩压降低，停药后恢复到原来水平，血、尿、发锌含量明显升高（P〈0．01），并且随锌摄入量的增加持续升高，Zn／Cu增大（P〈0．05～0、01），停药后血、发锌含量仍高于服前水平（P〈0．05～0．01），铜含量无变化（P〉0．05）。结论：口服葡萄糖酸锌后内环境锌铜代谢失衡，停锌后短期内不能恢复原来水平。

Objective：To observe the effects of high level Zinc intake on blood pressure, heart rate and the level of zinc（Zn） and copper （Cu） in man. Methods ： 38 healthy men with the same custom and food were chosen . All subjects were asked to administer zinc glucose （50mg/d） for 8 weeks and be examined for 4 times： at week 0,4,8 during the period of Zn supplementation and at week 4 after stopping Zn supplementation. At the same time, their blood, urine and hair were collected for measuring the contents of Zn and Cu. Results ：The subjects＇ SBP（systole blood pressure） decreased after Zn supplementation and returned to the original level after stopping supplementation. Zn contents in serum , urine and hair increased significantly （P〈 0.01 ） and rose continuously following the addition of Zn intake. Zn/Cu increased （P〈 0.05-0.01 ）. After stopping supplementation, Zn contents in serum and hair were still higher than those before supplementation （ P 〈 0.05 - 0.01）. Cu contents did not change significantly during experiment （ P 〈 0.05 ）. Conclusion ： The metabolism of Zn and Cu in men was in disorder after Zn supplementation and could not return to the original level in shout time after stopping Zn supplementation.