急性心肌梗死患者PCI术前后血清基质金属蛋白酶水平的变化及临床意义

Changes and clinical significance of plasma MMP-9 in acute myocardial infarction patients before and after PCI

目的 探讨血清基质金属蛋白酶-9（MMP-9）在急性心肌梗死患者急诊介入治疗前后的变化及临床意义。方法 采用酶联免疫吸附法（ELISA）检测50例行急诊经皮冠状动脉介入（PCI）术治疗患者及20例冠状动脉造影正常者术前及术后第1～7天血浆MMP-9的含量。结果 心肌梗死患者PCI术前及术后血浆MMP-9水平较对照组明显升高（P〈0.01），PCI术患者在术后第1天血浆MMP-9明显升高（198±59）μg/L，并在术后第2～3天达高峰，第4～5天开始显著下降。结论 MMP-9水平增加可能是心肌缺血再灌注损伤的机制之一，MMP-9水平升高可能与缺血再灌注后的炎症损伤有关。

Objective To explore the changes and clinical significance of matrix metalloproteinases- 9 （ MMP - 9） in acute myocardial infarction patients before and after PCI. Methods The plasma MMP - 9 level were measured in 50 acute myocardial infarction patients and 20 control subjects 1 -7 days after PCI by enzyme - linked immunosorbent assay （ELISA）. Results The level of MMP - 9 was significantly higher in AMI group than that in control group before and after PCI（ P 〈0.01 ）. The level of MMP-9 in AMI group began to increase on the first day and was at peak on 2 - 3 days, on 4 - 5 days after PCI it began to decrease. There was significant difference in plasma level of MMP - 9 in control group （ P 〉 0.05 ）. Conclusion The level of MMP- 9 may be related to inflammatory injuries after myocardial ischemia and reperfusion. The increase of MMP -9 may be one of the molecular mechanism of myocardial isehemia reperfusion injuries.