亚低温联合生脉注射液在心肺脑复苏中的应用

Clinical application of sub-hypothermia combined with Shengmai injection (生脉注射液) on cardiopulmonary cerebral resuscitation

目的:探讨亚低温联合生脉注射液在心肺脑复苏(CPCR)救治中的可行性及疗效。方法:选择本院急诊科收治心搏骤停行心肺复苏成功患者80例,采用随机数字表法分为亚低温组(43例)和对照组(37例)。两组患者给予复苏兴奋药物、降颅压、激素等基础复苏药;亚低温组同时联用大剂量生脉注射液。两组患者均在复苏即刻以及复苏后1、3和7 d进行格拉斯哥昏迷评分(GCS),同时抽取静脉血3 m l,检测血浆丙二醛(M DA)含量及尿酸(UA)浓度。结果:与治疗前比较,亚低温组治疗后GCS明显升高(P<0.05或P<0.01),M DA含量和UA浓度则均明显降低(P<0.05或P<0.01);而对照组治疗前后GCS、M DA和UA均无明显变化(P均>0.05)。结论:亚低温联合大剂量生脉注射液能明显改善CPCR患者的神经功能,是安全、有效、易于推广的CPCR途径。

Objective： To investigate the effect of sub-hypothermia combined with Shengmai injection （生脉注射液） on cardiopulmonary cerebral resuscitation. Methods ： Eighty patients with sudden cardiac arrest from the emergency department treated with the cardiopulmonary cerebral resuscitation successfully were randomly divided into sub-hypothermia treatment group （n = 43） and control group （n = 37）, Adrenalin, analeptic, drugs for lowering intracranial pressure, hormone and other basic medicine for resuscitation were used in the two groups. In addition, the patients in the treatment group were treated with a large doses of Shengmai injection. Glasgow coma scale （GCS） was recorded in each patient immediately, and 1, 3 and 7 days after resuscitation, at the same time, 3 ml venous blood was sampled to detect the concentration of malondialdehyde （MDA） and uric acid （UA）. Results： GCS was much higher and the levels of MDA and UA were decreased after treatment than those before treatment in the treatment group （P〈0.05 or P〈0. 01 ）, but the changes of GCS, MDA and UA levels were not significant after treatment compared to those before treatment （all P〉0.05） in the control group. Conclusion.. The sub-hypothermia combined with a large dose of Shengmai injection can improve the nerve function after cardiopulmonary cerebral resuscitation, which is safe, effective and easy to be popularized.