慢性肾功能衰竭患者环丙沙星药物动力学研究

Study on the pharmacokinetics of ciprofloxacin in patients with chronic renal failure

对８例健康志愿者，１１例慢性肾功能衰竭患者（Ｃｃｒ＜１０ｍｌ／ｍｉｎ）静脉恒速滴注乳酸环丙沙星２００ｍｇ（３０ｍｉｎ）注射液后的临床药物动力学进行了研究，用高效液相色谱法对血清中环丙沙星进行测定，主要药动学参数分别是滴注完时浓度Ｃｏ健康人组为２．２６ｍｇ／Ｌ，未透析组为２．５２ｍｇ／Ｌ，血透组为２．３７ｍｇ／Ｌ，腹透组为２．３５ｍｇ／Ｌ。清除相半衰期健康人为２．７±０．８ｈ，未透析组为１５±４ｈ，血透组为５．０±１．９ｈ，腹透组为６．３±２．７ｈ。表明慢性肾功能衰竭患者的环丙沙星药物动力学过程较健康者有明显的改变。

he clinical pharmacokinetics of ciprofloxacin was deternined following a iv dose of 200mg(30min)given to each 8 health volunteers,11 patients with chronic renal failure (Ccr<10ml/min).Ciprofloxacin concentration in serum was assayed by HPLC method.The levels of ciprofloxacin in serum at the end of 200mg iv were 2.26 mg/L in healthy subjects, 2.52 mg/L in patients non dialysis, 2.37 mg/L in patients with haemodialysis, 2.35 mg/L in patients with peritoneal dialysis.The serum half lives of clearence were 2.7 ± 0.8h in healty subjects, 15 ± 4h in patients non dialysis, 5.0 ± 1.9h in patients with haemodialysis, 6.34 ± 0.23h in patieits with peritoneal dialysis.The results showed the pharmacokinetic conrse of ciprofloxacin in patients with chronic renal failure was dovionusly different that compared with healthy subjects.These findings singgest that several ways of ciprofloxacin given can be put formard to patients with chronic renal failure.