人食管鳞癌中淋巴管的表达密度及意义

Density of lymphatic vessels and its clinical significance in human esophageal squamous cell carcinoma

目的探讨血管内皮生长因子受体3(VEGFR-3)在人食管鳞癌中的表达及其在淋巴管生成和淋巴结转移中的临床意义。方法采用免疫组织化学SP法,检测59例食管鳞癌手术标本组织中VEGFR-3的表达及定位特征,并用图像分析方法测定淋巴管数量和平均光密度(MOD),及其与淋巴结转移的关系。结果VEGFR-3表达与肿瘤淋巴结转移密切相关(P<0.05),癌组织和癌周组织VEGFR-3阳性淋巴管密度(LVD)和MOD也与淋巴结转移密切相关(P<0.01)。结论VEGFR-3与淋巴结转移、新生淋巴管的形成有相关性。

Objective To study the relationship between the expression of vascular endothelial growth factor receptor 3 （VEGFR- 3） and lymphangiogenesis in human esophageal squamous cell carcinoma （ESCC）. Methods VEGFR - 3 expression in ESCC tissues from 59 cases was detected by the immunohistochemical SP method and the image analysis system. The relationship between VEGFR - 3 and lymphangiogenesis was analyzed by calculating the number of lymphatic vessel density （LVD）. Results There was a statistically positive correlation between VEGFR - 3 expression and lymph node metastasis in primary tumors （ P 〈 0.05）. The number and mean optical density （MOD） of VEGFR - 3 positive lymphatic vessels in the tumor and peritumoral tissue were also closely related to the lymph node metastasis of ESCC（P〈0.01）. Conclusion There is a close relationship between VEGFR - 3 and lymphangiogenesis in ESCC.