摘要
用羟丙甲基纤维素邻苯二甲酸酯(HPMCP)为囊材,将磺胺嘧啶包成微型胶囊,并对微囊的主药含量,及其体外释放进行了研究。结果在人工肠液中累积释放曲线的3个主要参数为T5029.96±0.06min;Td35.23±0.15min;m1.76±0.03。
HPMCP is enteron soluble material.It can resist the gastric acid and had good dissolution property in enteron.Using HPMCP as a wall material of the microcapsules of sulfadiazium had been studied. The results of vitro dissoluting tests showed that in two hours the microcapsules of sulfadiazium released very little in simulated gastric fluid and all released in artifical intestinal liquid.The T 50 , T d and m was 26.96 ± 0.06min , 35.23 ± 0.15min , 1.76 ± 0.03 .
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1996年第10期451-452,共2页
Chinese Journal of Hospital Pharmacy
关键词
磺胺嘧啶
微囊
HPMCP
sulfadiazium,microcapsules,HPMCP (Original article on page 451)