环孢素A血药浓度监测63例分析

Analysis of the cyclosporine blood concentration monitoring with 63 post kidney transplant patients

对６３例肾移植患者（男４７例，女１６例）术后环孢素Ａ全血浓度常规监测进行了统计分析，其中有２６例术后发生排异反应，以第２年为最多，其次是４～１２个月。１９８份血样测定结果统计分析表明，术后排异反应组与无排异反应组之间给药剂量及环孢素Ａ血浓度存在显著性差异（Ｐ＜０．０５），男女患者排异反应发生率有较大区别。在合并用药中，发现酮康唑能显著升高环孢素Ａ血浓度，与已有报道一致。

he routine monitoring data of cyclosporine blood concentration from 63 post kidney transplant patients were statistically analyzed.26 patients suffered rejection after transplantation.The most of rejection was in the second year of post transplantation,the next was in 4-12 monthes.The demographic results of 198 determined samples appeared that dosages and cyclosporine blood levels had significant difference between rejection and unrejection ( P < 0.05 ),and the incidence of rejection had more difference between male and female.Ketoconazole could significantly increased cyclosporine blood level in combination,which accorded with published report.