快速高效液相色谱法测定丙酸倍氯米松喷雾液的含量

HPLC determination of beclometasone dipropionate spray

本文建立了快速高效液相色谱法测定喷雾液中的丙酸倍氯米松含量的方法。以地西泮为内标，甲醇∶水（７０∶３０）为流动相，检测波长为２４０ｎｍ，其浓度在５～３５μｇ／ｍｌ范围内呈良好的线性关系，ｒ＝０．９９９８，平均回收率（ｎ＝６）为１００．２％，ＲＳＤ为１．４６％。方法快速，灵敏，准确，简便。

fast HPLC method is described for the determination of beclometasone dipropionate spray,chromatographic conditions were:column,Econosphere C 18 5μ 5×50mm;mobile phase,methanol:water (70∶30);internal standard,diazepam,flow rate 2ml/min,detected at 240nm.Average recovery ( n =6) was 100.2% , RSD was 1.46% .It showed that the method was simple and fast.