患者血清CA199,CA724联合检测对胃癌的诊断价值

The Diagnostic Value of Combined Determination of Serum CA199 and CA72-4 in the Patients with Gastric Cancer

目的:探讨联合检测CA199和CA724在胃癌诊断中的价值。方法:选择胃癌43例,正常健康体检者36例,分别采用电化学发光分析法测定CA199、CA724。结果:胃癌组CA199及CA724的测定值分别为(67.1±34.6)KU/L、(39.62±62.13)KU/L,明显高于正常健康人对照组,两组比较,差异非常显著(P<0.01),胃癌单用CA199和CA724检测,其阳性率分别为46.5%,51.2%,联合检测阳性率为74.4%。结论:实验室检测肿瘤标志物,单项检测容易出现漏诊,联合检测可提高阳性率。

Objective： To investing the value of the tumor marker CA199 and CA72- 4 in human serum in diagnosis of gastric cancer. Methods： The concentrations of CA199 and CA72 - 4 in the serum of forty - three patients with gastric cancer and thirty - six healthy controls using electrochemiluminescene analyzer was evaluated. Results： The levels of CA199 and CA72 - 4 in the cancer group were 67.1 ± 34.6KU/L and 39.62 ± 62.13KU/L, which were significantly higher than those in the healthy control group （ P 〈 0.01 ）. In the gastric cancer group, the positive rate of serum CA199 or CA72 - 4 was 46.5% or 51.2% when the determination was done solely for CA199 or CA72 - 4. The total positive rate of gastric cancer, s markers rose to 74.4% when the two parameters determined simultaneously. Conclusion ： Neglect of colonic - rectal cancer may occur if the marker is determined solely, but its positive rate can be increased under the condition of combined determination.