缺血性脑卒中患者凝血和纤溶的变化

Alteration of Coagulation and Fibrinolysis in Plasma on Patients with Ischemic Stroke

目的探讨缺血性脑卒中患者凝血和纤溶的变化。方法采用酶联免疫(ELISA)、发色底物、免疫比浊和凝固等方法定量分析缺血性脑卒中患者组织纤溶酶原激活剂(tPA)、纤溶酶原激活剂抑制物-1(PAI-1)、凝血酶(AT)、D二聚体(D-D)、纤维蛋白原(Fbg)和血小板聚体率(PAgT),分别与对照组凝血纤溶各项指标比较。结果脑梗死组PAgT、D-D、Fbg结果高于对照组(P＜0.05)；AT低于对照组；tPA低于对照组(P＜0.01)；PAI-1高于对照组(P＜0.01)。结论缺血性脑卒中患者存在明显的凝血和纤溶系统的异常。

Objective The assay is to study blood alteration of and fibrinolysis in patients with ischeminogen activator inhibitor-1 （ PAI-1 ）, D-Dimer, antithrombin （ AT）, Fibrinogen （Fbg）, PAgT. Results Data of IS group were compared with the control group, showing that PAgT, D-Dimer and Fbg were obviously higher （ P 〈 0.05 ）, as well as the PAI-1 （ P 〈 0.01 ）. Whilst, the AT were lower （ P 〉 0.05 ） and tPA （ P 〈 0.01 ）higher. Conclusion There is significant abnormal in coagulation and fibrinolysis system in patients with IS.