网状组织细胞增生症组织病理及免疫组化研究

Pathological immunohistochemical analysis in reticulohistiocytosis

观察１例多中心网状组织细胞增生症和５例网状组织细胞肉芽肿（ＲＨ）病理表现，两病均由甲状腺嗜酸细胞样单核组织细胞和多核组织细胞组成，在ＲＨ还可见空泡状、棘状和黄瘤样单核组织细胞。免疫组化示：ＫＰ１（ＣＤ６８）、溶菌酶、ａ１－抗胰蛋白酶、花生凝集素和Ｖｉｍｅｎｔｉｎ阳性，Ｍａｃ（３８７），Ｓ－１００，ＨＬＡ－ＤＲ、Ｄｅｓｍｉｎ、Ａｃｔｉｎ阴性，讨论两病的组织病理、免疫组化鉴别及ＲＨ与成人黄色肉芽肿关系。

The skin biopsy specimens from a case of multicentric reticulohistiocytosis(MR)and five cases of reticulohistiocytoma(RH)were studied. Both entities consisted of oncocytic mononuclear histiocytes and multinucleated histiocytes.In RH vacuolated,spindleshaped and xanthomatized mononuclear histiocytes were also present.Immunohistochemical profiles showed KP1(CD(68)),lysozyme α-antitrypsin,peanut agglutinin and vimentin.MAC 387,S-100,HLA-DR,desmin and actin were negative.The study shows that histopathological analysis supplemented by immunocytochemistry delineates MR from RH and immunohistochemical profiles indicate a cell lineage relationship between RH and adult xanthogranuloma.