23例原发性十二指肠癌临床病理与免疫组化分析

23 cases of primary duodenal carcinoma:a clinicopathologic and immunohistochemical study

应用免疫组化方法和临床病理资料对２３例十二指肠癌加以分析。结果表明：原发性十二指肠癌患者发病高峰期为５０～６０岁，肿瘤发生在乳头部最多见（１５例，占６５％）．在组织学分型上，以管状腺癌（１２例）和乳头状腺癌（７例）多见。免疫组化染色显示，１１例病人伴有神经内分泌细胞分化，其中伴有胰多肽表达者９例，胃泌素８例，生长抑素４例，胰高血糖素３例，两种激素同时表达者４例，三种激素表达者４例，单一激素表达者３例。本文就原发性十二指肠癌伴神经内分泌细胞分化的组织发生加以讨论。

A clinicopathologic and immunohistochemical study of 23 cases of primary duodenal carcinomas was performed.The results showed that it occurred predominantly in the age of 50～60.Most of these neoplasms were located in the duodenal papilla(15 cases,65%).Histologically,tubullar adenocarcinoma(12 cases)and papillary adenocarcinoma(7 cases) were the main type.In immunohistochemical staining,11 of the 23 tumors were positive for neuroendocrine cell markers,of which pancriatic polypeptide was expressed in 9 patients,gastrin in 8,somatostatin in 4 and glucogan in 3 patients.The two kinds of hormones were found in 4 tumors,three in 4 and one kind of hormone in 3 tumors.The histogenesis of duodenal carcinoma with neuroendocrine cell differetiation was discussed.