甲状腺粘膜相关淋巴瘤与淋巴细胞性甲状腺炎的临床病理及免疫组化研究

Clinical pathology and immunohistochtry of thyroid MALT lymphoma and lymphocytic thyroiditis

报道甲状腺粘膜相关淋巴瘤１２例，淋巴性甲状腺炎６例。淋巴性甲状腺炎分为轻、中、重三级。研究上述１８例有免疫组化结果的资料，发现粘膜相关淋巴瘤多见于老年女性，并从淋巴细胞性甲状腺炎发展演变而来，以中心细胞样细胞为多见，免疫组化示Ｂ－细胞性单克隆性。组织病理学上常形成淋巴上皮病变，瘤栓样或戒指样结构。本文探讨了淋巴性甲状腺炎与甲状腺粘膜相关淋巴瘤的发病机理、鉴别诊断及治疗方法的选择等。

Thyroid mucosa-associated lymphoid tissue(MALT)lymphoma(twelve cases)and lymphocytic thyroiditis(six cases)were studied.The lymphocytic thyroiditis were graded into mild,moderate and severe grade.MALT lymphoma usually occured in female patients and developed from lymphocytic thyroiditis.The main subtype was centrocytoid.The lympho-epithelial lesion,tumor emboli or ring like structure were common.Immunohistochemistry showed it was monoclonal B cell lymphoma of the twelve cases.The mechanism of this disease,differential diagnosis and selection of the treatment were also discussed.