射频消蚀对心肌结构影响的实验研究

Experimental study of effects of radiofrequency ablation on cardiac muscle structure

经导管对犬和兔心房、心室行射频消蚀，观察消蚀后心肌结构的变化及消蚀能量与心肌损伤程度的关系。结果显示：射频消蚀引起的心肌损伤范围局限、坏死彻底，损伤区由肉芽组织和纤维瘢痕替代；在２０～５００Ｊ的射频输出范围内，消蚀损伤程度与能量输出呈正相关；射频消蚀也应有限量地进行，过多或大范围的消蚀可引起弥漫性的心内膜增厚。同时时消蚀后心肌损伤的组织学、超微结构变化与细胞电生理改变的关系进行了讨论。

Radiofrequency catheter ablation(RFCA)was performed on dog's and rabbit's atrium and ventricle to observe the structural alterations of heart muscle with the change of ablation energy.The results showed that the lesions caused by RF was coagulative necrosis,and localized and replaced by granulous and fibrous tissue.In the range of 20～500 J,the grade of ablation lesion was directly proportional to the output of energy.The relationship of histologic,ultrastructural,and cell electrophysiologic changes after radiofrequency ablation was discussed.