加拿大产西洋参根中的两个C_(20)侧链变化的达玛烷型人参皂苷

Two Varied-in-C_(20)-sidechain Dammarane-type Sapoins From Radix of Panax quinquefolium L.

目的:对加拿大魁北克地区产西洋参进行化学成分研究。方法:西洋参干燥根用70%醇提物用大孔吸附树脂,硅胶开放柱,ODS开放柱,制备薄层及制备型高效液相色谱等方法进行分离纯化,利用波谱数据,理化分析并结合文献对分得的化合物进行鉴定。结果:分离得到8个皂苷类成分,分别为人参皂苷Rg1(1),Rg2(2),20(R)-Rg2(3),Rd(4),Re(5),GinsenosideⅢ(6),Majoroside-F1(7)andRb1(8)。结论:Majoroside-F1,GinsenosideⅢ为C20侧链发生变化的达玛烷型人参皂苷,GinsenosideⅢ为从西洋参中首次分离的化合物,Majoroside-F1为首次在西洋参根中得到的化合物。

Objective： To study the chemical constituents of Panax quinquefolium L. from Quebec district of Canada. Methods： The dried root of the title plant was extracted by 70% ethanol, and subject by silica gel, ODS column, HPLC. The chemical constitute＇s structure were illustrated by the use of physico - chemical analysis, spectroscopic analysis as well as correlative literature. Results： Eight saponins were obtained and their structure were identified as Rg1 （1）, Rg2 （2）, 20 （R） - Rg2 （3）, Rd （4）, Re （5）, Ginsenoside Ⅲ （6）, Majoroside-F1 （7） and Rb1 （8）. Conclusion： Two dammarane-type saponins varying in C20 - sidechain-compound 6 and 7-were isolated from Panax quinquefolium L., and confound 6 were first found in the title plant. And compound 7 were first found in the root of the title plant.