卡介菌多糖-核酸穴位注射治疗慢性荨麻疹的临床疗效观察

Therapeutic effect of BCG polysaccharide and nucleic acid preparation on chronic urticaria by point injection

目的观察卡介菌多糖-核酸注射液穴位注射治疗慢性荨麻疹的临床疗效和安全性。方法将125例患者分为3组,全部患者均于每晚睡前口服左西替利嗪1片(5 mg),A组(42例)于双侧曲池、足三里穴注射卡介菌多糖-核酸注射液[1次/3 d,1 mg(2支)/次];B组(42例)肌肉注射卡介菌多糖-核酸注射液[1次/2 d,1mg(2支)/次];C组(41例)不加其他药物治疗。疗程均为6周。结果治疗后,A、B、C组的总有效率分别为47.61%、42.85%、29.27%(2周),71.66%、69.02%、39.02%(4周);85.71%、83.05%、47.48%(6周)。A组疗效与B组比较,无显著性差异(P>0.05);A组总有效率与C组比较,有显著性差异(P<0.05)。3组均无明显不良反应。结论卡介菌多糖-核酸注射液穴位注射治疗慢性荨麻疹临床疗效好,其疗效随着治疗时间的延长而提高。

Objective To observe the therapeutic effect and safety of BCG polysaccharide and nucleic acid preparation on chronic urticaria by point injection. Methods One hundred and twenty-five cases were randomized into three groups. All patients received levocetirzime hydrochloride （5 mg, po） before sleep every night, on the basis of this, A group （42 cases） was injected with BCG polysaccharide and nucleic acid preparation in both side of ＂Tsusanli and Bend Pond＂ point [ 1 mg（2 branches）, every 3 d for 1 dose]. B group （42 cases） received BCG polysaccharide and nucleic acid preparation [ 1 mg（2 branches）, every 2 d for 1 dose, im]. C group （41 cases） didn＇t use another drugs. The period of treatment were 6 weeks for all patients. Results The total effective rate of A, B, C group： 47.61%, 42.85 %, 29.27 % （2 weeks） ;71.66%, 69.02%,39.02% （4 weeks） ;85.71%, 83.05%, 47.78% （6 weeks）. The difference of therapeutic effect between A and B group was not evident （P 〉 0.05） ; and there was significant difference of effective rate between A and C group （P 〈 0.05）. Conclusion BCG polysaccharide and nucleic acid preparation have good therapeutic effect on chronic urticaria by point injection, and the effect could advance along with the prolong of period of treatment.