卵巢上皮性肿瘤CD_(105)标记的微血管密度的研究

The study of microvessel density marked with CD_(105)in epithelial ovarian tumour

目的探讨卵巢上皮性肿瘤CD105表达及其标记的微血管密度(MVD)与肿瘤发生、发展的关系。方法应用免疫组织化学法检测25例良性肿瘤,10例交界性肿瘤和24例恶性上皮性肿瘤中CD105的表达及MVD。结果59例卵巢上皮性肿瘤中,CD105标记的MVD在恶性肿瘤中显著高于交界性及良性肿瘤(P<0.01),CD105标记的恶性肿瘤中MVD与肿瘤临床分期、病理分级、患者年龄无统计学相关性(P>0.05)。结论CD105标记的MVD与卵巢上皮性肿瘤恶性进展相关,但不能作为卵巢上皮性恶性肿瘤的预后指标。

Objective To investigate the correlation between microvessel density （MVD） marked with CD105 and the development of epithelial ovarian tumour. Methods Expression of CD105 protein and MVD were examined by immunonistochemical technique in 25 cases of benign tumour, 10 cases of borderline tumour and 24 cases of malignant epithelial ovarian tumours. Results The average MVD was higher in the malignant cases than those in benign and borderline cases （P 〈 0.01）.The MVD were not related to the tumour＇s pathological grade,clinical stage and patient＇s age （P 〉 0.05）. Conclusion The MVD labeled by CD105 is correlated with progression of epithelial ovarian tumour, MVD in epithelial ovarian tumour can not act as predictor factor.