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胰岛素样生长因子-Ⅰ与乳腺癌 被引量：2

Insulin-like Growth Factor-Ⅰ and Breast Cancer
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摘要 胰岛素样生长因子Ⅰ(insulinlikegrowthfactor,IGF)对细胞增殖和凋亡具有双重调节功能。在临床上,它的异常伴随着多种慢性疾病或肿瘤倾向;在乳腺癌的发生发展过程中,其作用也异常重要。深入研究其功能及相关影响因素,将为临床乳腺癌的诊疗提供新思路和新办法。 A new cancer-relating factor, the insulin-like growth factor-Ⅰ （IGF-Ⅰ）, has dual functions in the cellular proliferation and apoptosis. In clinical practice, the abnormal level of this factor was always associated with chronic disease or tumor. IGF-Ⅰ plays an important role in the growth of breast cancer, the second commonest cancer in women. The in-depth study of its functions and influencing factors will provide new ideas and approaches for the treatment of breast cancer.
作者 任玉萍 吴毅平
机构地区 华中科技大学同济医学院附属同济医院普通外科
出处 《医学分子生物学杂志》 CAS CSCD 2006年第4期309-312,共4页 Journal of Medical Molecular Biology
关键词 胰岛素样生长因子-Ⅰ 乳腺癌 the insulin-like growth factor-Ⅰ breast cancer
分类号 R730.2 [医药卫生—肿瘤]
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参考文献20

  • 1[1]ROSEN C J,POLLAK M.Circulating IGF-1:New perspectives for a new century[J].TEM,1999,10:136-141.
  • 2[2]TWIGG S M,BAXTER R C.Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid labile subunit[J].J Biol Chem,1998,273:6074-6079.
  • 3[3]SCHERNHAMMER E S,HOLLY J M,POLLAK M N,et al.Circulating levels of insulin-like growth factors,their binding proteins,and breast cancer risk[J].Cancer Epidemiology,Biomarkers & Prevention,2005,14(3):699-704.
  • 4[4]CHENG M,ZAMAN G,RAWLINSON S C,et al.Mechanical strain stimulates ROS cell proliferation through IGF-2 and estrogen through IGF-1[J].J Bone Miner Res,1999,14(10):1742-1750.
  • 5[5]KOEDAM J A,HOOGERBRUGGE C M,VAN BUUL-OFFERS S C.Differential regulation of IGF-binding proteins in rabbit costal chondrocytes by IGF-Ⅰ and dexamethasone[J].J Endocrinol,2000,165(3):557-567.
  • 6[6]HURSTING S D,LAVIGNE J A,BERRIGAN D,et al.Diet-gene interactions in p53-deficient mice:insulin-like growth factor-Ⅰ as a mechanistic target[J].J Nutr,2004,2482s-2486s.
  • 7[7]NEUBERG M,BUCKBINDER L,SEIZINGER B,et al.The P53/IGF-1 receptor axis in the regulation of programmed cell death[J].Endocrine,1997,7(1):107-109.
  • 8[8]WALDEN P D,RUAN W,FELDMAN M,et al.Evidence that the mammary fat pad mediates the action of growth hormone in mammary gland development[J].Endocrinology,1998,139:659-662.
  • 9[9]KLEINBERG D L,FELDMAN M,RUAN W,et al.IGF-1:An essential factor in terminal end bud formation and ductal morphogenesis[J].Mammary Gland BioL Neoplasia,2000; 5 (1):7-17.
  • 10[10]WU Y,CUI K,MIYOSHI K,et al.Reduced circulating insulinlike growth factor I levels delay the onset of chemically and genetically induced mammary tumors[J].Cancer Res,2003,63 (15):4384-4388.

二级参考文献12

  • 1Miyoshi K,Shillingford J M,Le Provost F,et al.Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias.Proc Natl Acad Sci USA,2002,99:219-24.
  • 2Satyamoorthy K,Li G,Vaidya B,et al.Insulin-like growth factor-Ⅰ induces survival and growth of biologically early melanoma cells through both the mitogen-activated protein kinase and beta-catenin pathways.Cancer Res,2001,61:7 318-24.
  • 3Desbois-Mouthon C,Cadoret A,Blivet-Van Eggelpoel MJ,et al.Insulin and IGF-Ⅰ stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation.Oncogene,2001,20:252-9.
  • 4Yakar S,Liu JL,Fernandez AM,et al .Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity.Diabetes,2001,50:1 110-8.
  • 5LeRoith D,Baserga R,Helman L,et al.Insulin-like growth factors and cancer.Ann Intern Med,1995,122:54-9.
  • 6Wu Y,Yakar S,Zhao L,et al.Circulating Insulin-like growth factor-I regulate colon cancer growth and metastasis.Cancer Res,2002,62:1 030-5.
  • 7Ruggeri BA,Klurfeld DM,Kritchevsky D,et al.Growth factor binding to 7,12-dimethyl-benz(a)anthracene-induced mammary tumors from rats subject to chronic caloricrestriction.Cancer Res,1989,49:4 135-41.
  • 8Craig-Schmidt M,White M T,Teer P,et al.Menhaden,coconut,and corn oils andmammary tumor incidence in BALB/c virgin female mice treated with DMBA.Nutr Cancer,1993,20:99-106.
  • 9Baserga R.The insulin-like growth factor Ⅰ receptor:a key to tumor growth? Cancer Res,1995,55:249-52.
  • 10Ma J,Pollak MN,Giovannucci E,et al.Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-Ⅰ and IGF-binding protein-3.J Natl Cancer Inst,1999,91:620-5.

共引文献2

同被引文献15

  • 1Mathur SP,Mathur RS,Gray EA,et al. Serum vascular endothelial growth factor-C (VEGF-C) as a specific biomarker for advancedcer- vical cancer: relationship to insulin-like growth factor II (IGF-II), IGF binding protein 3 (IGF-BP3)and VEGF-B [J]. GynecolOnco, 2005,98 : 467-483.
  • 2Vikhlyera EM,WU YP. The relationship between IGF-2 and breast cancer[J]. Journal of Medical Molecular Biology, 2006,3 (4) : 309-312.
  • 3Li SR,Chungfar Jeremy NG,Ayan Banerjea,et al. Bustin differential expression patterns of the insulin-like growthfactor 2 fene in human colorectal cancer[J].Tumor Biol, 2010,25 : 62-68.
  • 4Byrne AT, Southgate J, Brison DR, et al. Effects of insulin-like growth factors I and II on tumour-necrosis-factoralpha-induced apoptosis in early murine embryos[J]. Reprod Fertil Dev,2009,14:79-83.
  • 5Katayama K,Ohtsuka R,Takai H,et al. Expression of p53 and its transcription target genes mRNAs in the ethylnitrosourea-induced apoptosis and cell cycle arrest in the fetal central nevous system[J]. Histol Histopathol, 2008,17 (3) : 715-720.
  • 6Baek WK,Kim D,Jung N,et al. Increased expression of eyclinGl in leiomyoma compared with normal myometrium [J]. Am J Obstet Gy- neeol, 2009,188 ( 3 ) : 634-639.
  • 7Shimizu A,Nishida J,Ueoka Y,et al. Cyelin G contributes to G2/M arrest of cells in response to DNA damage [J]. Biochem BiophysRes Commun, 1998,242 ( 3 ) : 529-533.
  • 8Yamauchi H,Katayama K,Ueno M,et al. Involvement of p53 in - beta-D,arabinofuranosylcytosine-indueed rat fetal brain lesions[J]. Neurotoxicol Teratol, 2004,26 (4) : 579-5862.
  • 9石殿鹏,李道堂,仲伟霞.食管癌中PCNA基阕蛋白的表达及意义[J].中华中西医杂志,2011,2(9):779.
  • 10Zhai YL,Kobayashi Y,Mori A,et al. Expression of steroid receptors, Ki-67,and p53 in uterine leiomynsarcomas[J], lnt J Gyneco] Pathol, 2009,18:20-28.

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二级引证文献9

医学分子生物学杂志
2006年 第4期

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