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机械生长因子的结构与调节 被引量：1

Structure and Regulation of Mechano Growth Factor
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摘要 机械生长因子(mechanogrowthfactor,MGF)起源于胰岛素生长因子Ⅰ(insulinlikegrowthfactorⅠ,IGFⅠ),与肝型IGFⅠ基因有着不同的3′端序列。MGF的表达主要受机械剌激和局部组织损伤的影响,且比肝型IGFⅠ具有增加肌肉质量的能力;机械刺激后幼年骨骼肌MGF表达先于其它IGFⅠ异构体,且MGFmRNA水平与年龄及生长激素有密切关系。 Mechano Growth Factor （MGF） is derived from the insulin-like growth factor （IGF- Ⅰ ）, and has a 3＇-sequence and a mode of action that are different from liver IGF- Ⅰ . MGF is expressed by mechanically overloaded muscle and is involved in tissue repair. Moreover, MGF is very potent and much more effective in increasing muscle mass than the liver IGF- Ⅰ . Following mechanical strain and/or muscle damage , the expression of young bone muscles fakes place befor the other IGF-Ⅰ, and MGF mRNA levels bear a close relationship with age and growth hormone
作者 史仍飞 危小焰
机构地区 上海体育学院运动科学学院
出处 《医学分子生物学杂志》 CAS CSCD 2006年第4期316-319,共4页 Journal of Medical Molecular Biology
基金 国家自然科学基金(No.10572097) 上海市自然科学基金(05ZR14111) 上海市第二期重点学科建设项目(No.T0901)~~
关键词 机械生长因子 生长激素 骨骼肌 运动 mechano growth factor growth hormone skeletal muscle, exercise
分类号 R872 [医药卫生—运动医学]
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参考文献25

  • 1[1]GOLDSPINK G.Research on mechano growth factor:its potential for optimising physical training as well as misuse in doping[J].Bri J Sports Med,2005,39:787-788.
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同被引文献6

  • 1鲜成玉,王远亮,唐丽灵.IGF-1剪接变构体:力生长因子[J].生理科学进展,2005,36(4):322-324. 被引量：4
  • 2GOLDSPINK G . Impairment of IGF - I Gene Splicing and MGF Expression Associated with Muscle Wasting [ J ]. The Inter-national Journal of Biochemistry & Cell Biology, 2006,38 : 481-489.
  • 3APERGHIS M,JOHNSON I P,CANNON J,et al. Different Levels of Neuro Protection by two Insulin-like Growth Factor-I Splice Variants [J]. Brain Res, 2004,1009 : 213-218.
  • 4HAMEED M ,ORRELL R W,COBBOLDd M ,et al. Expression of IGF-I Splice Variants in Young and old Human Skel- etal Muscle after High Resistance Exercise [J]. J Physiol, 2003,547: 247-254.
  • 5于文国,陶秀娥.包涵体蛋白复性及其影响因素[J].河北工业科技,2007,24(5):314-316. 被引量：12
  • 6杨晓仪,林键,吴文言.重组蛋白包涵体的复性研究[J].生命科学研究,2004,8(2):100-105. 被引量：33

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医学分子生物学杂志
2006年 第4期

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