苯扎贝特对中老年高血压代谢综合征患者的影响

Effect of bezafibrate on middle-senior aged hypertensive patients with metabolic syndrome.

目的探讨苯扎贝特对中老年高血压代谢综合征患者各代谢因素的影响。方法将55例中老年高血压代谢综合征患者分为2组:苯扎贝特组28例给予缓释硝苯地平、苯扎贝特并饮食控制;对照组27例给予缓释硝苯地平、安慰剂并饮食控制。观察治疗前后血压、体质指数、血脂、空腹血糖、胰岛素、胰岛素抵抗指数及尿酸水平等变化。结果2组血压水平均有明显下降,苯扎贝特组治疗后舒张压降低较对照组显著(P<0.05);苯扎贝特组血甘油三酯、总胆固醇、低密度脂蛋白胆固醇水平明显降低(P<0.05或0.001),高密度脂蛋白胆固醇显著升高(P<0.05),空腹血糖及胰岛素浓度降低(P<0.05),胰岛素敏感性升高(P<0.05),血尿酸水平明显下降(P<0.01)。结论苯扎贝特有可能改善中老年高血压代谢综合征患者的多种代谢异常因素。

Objective To investigate the effect of bezafibrate on middle-senior aged hypertensive patients with metabolic syndrome. Methods 55 hypertensive patients with metabolic syndrome were divided into two groups. The patients of group A （n =28） were treated with bozafibrate,nifedipine and dietary control,and those of group B（n =27） received plaeebo,nifedipine and dietary control. The changes of blood pressure （BP） ,body mass index,serum lipid,uric acid,plasma glucose,insulin nesistanee index and insulin level were observed. Results All patients had a great reduction in blood pressure. The diastolic blood pressure in group A was significantly decreased compared with that of group B（P 〈 0.05）, and the levels of triglyeeride, total cholesterol,low-density lipoprotein cholesterol were obviously decreased（ P 〈 0.05 or 0.01 ） but the levels of high-density lipoprotein cholesterol were significantly increased. The levels of fasting blood glucose and insulin（ P 〈0.05 ） as well as uric acid（0. 01 ） were decreased after treatment but insulin sensitivity was （P 〈 0.05 ） increased. Conclusion Bezafibrate may improve metabolic abnormalities of middle-senior aged patients.