摘要
目的探讨通心络与阿司匹林联合或替代治疗对血小板聚集率的影响。方法选取接受阿司匹林治疗的患者302例。根据血小板聚集率筛选阿司匹林抵抗患者。按时间顺序入组,以洗脱方式分组。停用阿司匹林2周,服通心络8粒+阿司匹林100mg/d,1个月,再停药2周,服通心络8粒/d,1个月。复查血小板聚集率。结果302例患者中58例存在阿司匹林抵抗,占19.2%。通心络+阿司匹林组与通心络组服药后1个月血小板聚集率均明显下降(均为P<0.05)。结论通心络可以降低血小板聚集率,对于阿司匹林抵抗患者,选用通心络治疗可以取得一定的疗效。
Objective To study the effect of combination of Tongxinluo and aspirin or supplementary therapy on platelet aggregation rate. Methods 302 cases treated with aspirin were selected according to platelet aggregation rate, who were divided by washing methods. 2 weeks later after aspirin was stopped, the patients were given Tongxinluo 8 tablets a day plus aspirin 100mg/d for 1 month, and then another 2 weeks later the patients were only given Tongxinluo 8/d for 1 month. The platelet aggregation rate was measured. Results Of 302 cases, 58 cases developed aspirin resistance （ 19.2% ）. Platelet aggregation rate was significantly decreased after 1 month of appceation of tongxinluo in the two oroups（P 〈 0.05 for each）. Conclusion Tongxinluo may reduce platelet aggregation rate and produce certain therapeutic effect for the patients with aspirin resistance.
出处
《中国综合临床》
北大核心
2006年第9期778-779,共2页
Clinical Medicine of China
关键词
阿司匹林抵抗
通心络
血小板聚集
Aspirin resistance
Tongxinluo
Platelet aggregation
