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大肠癌组织中细胞核转录因子/P50的表达与临床病理特征的关系研究 被引量:1

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摘要 目的探讨大肠癌组织中细胞核转录因子NF-κB/P50的表达与临床病理特征的关系。方法应用免疫组化法检测66例大肠癌组织的NF-κB/P50的表达。结果大肠癌组织中NF-κB阳性表达率在有淋巴结转移组为74.1%(20/27),明显高于无淋巴结转移组的48.7%(19/39)(χ2=4.24,P<0.05),在Dukes分期C+D组为83.3%(25/30),明显高于A+B组的38.9%(14/36)(χ2=13.37,P<0.01)。结论NF-κB/P50与大肠癌的淋巴结转移和Dukes分期密切相关。
出处 《中国综合临床》 北大核心 2006年第9期811-813,共3页 Clinical Medicine of China
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同被引文献5

  • 1鲁秀敏,王永堂,余瑛,杨艳红.NF-κB与神经损伤[J].山东医药,2006,46(5):79-80. 被引量:4
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  • 4Laurence J , Murat T. NF - B signaling pros and cons of altering NF - KB as a therapeutic approach [ J ]. Ann N YAcad Sci, 2006,1072 : 114 - 122.
  • 5Shishodia S, Aggarwal BB. Cyclooxygenase (COX)-2 inhibitor cele- coxib abrogates activation of cigarette smoke-induced nuclear factor (IVF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation wit h suppression of cyclin D1, COX-2, and mat rixmetalloproteinase-9 [ J ]. Cancer Res, 2004,64(14) :5004 -5012.

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