甲状腺功能障碍对leptin水平的影响

Influence of thyroid dysfunctional status on leptin

目的探讨甲状腺功能障碍对人体血清leptin水平的影响。方法选取甲亢患者45例、甲减患者46例、正常对照组50例,应用免疫放射分析(IRMA)法测定血清leptin水平,并测甲状腺功能,计算体重指数(BMI)和体脂百分数(%Fat)。结果甲亢患者leptin水平,男性(2.05±1.54)μg/L,女性(7.47±5.08)μg/L,显著低于正常组,而且扣除体脂因素后仍很明显(P<0.01)。甲减组leptin水平与正常组相比显著升高,但排除体脂因素后,两组差异无显著性。3组leptin水平均与BMI显著正相关,与游离三碘甲状腺原氨酸(FT3)。游离甲状腺素(FT4)呈弱负相关,与促甲状腺激素(TSH)呈弱正相关,但无统计学意义。各组中女性leptin水平均为男性的2、3倍。结论甲功改变通过体脂含量间接影响leptin水平。

[Objective] To investigate the levels of serum leptin in different status of thyroid function. [Methods] Serum leptin levels were measured by IRMA in hyperthyroidism as well as hypothyroidism and normal subjects as control. Serum thyroid-stimulate hormone （TSH）, free T3 and free T4 （F3 and FT4） were measured. Body fat percentage （%Fat） and body mass index （BMI）were calculated. [Results] Compared with normal controls, serum leptin levels were significantly lower in hyperthyroidism patients [male （2.05±1.54） μg/L, female （7.47±5.08）μg/L], and clearly higher in hypothyroidism patients. But excluded the body fat factor, there was no obvious difference in hypothyroidism. Serum leptin levels in 3 groups were significantly correlated with BMI. They were lightly negatively correlated with FT3, FT^4, and lightly positively correlated with TSH. But the correlativity was not significant. Serum leptin levels were 2, 3 times higher in women than in men among 3 groups. [Conclusion] Thyroid functional status affected serum leptin levels indirectly by body fat factor.