奈达铂联合氟尿嘧啶/醛氢叶酸双周疗法治疗晚期头颈部癌

Clinical observation of nedaplatine combined with bimonthly 5-fluorouracil(5-FU)/leucovorin(LV) in the treatment of advancd head and neck carcinoma

目的观察奈达铂(NDP)和5-氟尿嘧啶(5-FU)/醛氢叶酸(LV)双周疗法治疗头颈部癌的疗效和不良反应。方法28例晚期头颈部癌患者用奈达铂100 mg/m2,静脉输注,第1天;LV 200 mg/m2,静脉滴注2小时,5-FU 500 mg静脉推注,然后5-FU 2.8 g/m2持续48小时静脉滴注,第1、15天;每4周重复1次。所有病例至少接受两个疗程治疗。结果完全缓解2例(7.14%),部分缓解13例(46.43%),总有效率为53.57%。对于既往使用过顺铂(DDP)的病例中,有效率为40.0%。不良反应主要为骨髓抑制、黏膜炎和腹泻,无治疗相关死亡。结论奈达铂联合大剂量醛氢叶酸+5-氟尿嘧啶持续滴注48小时这一方案治疗晚期头颈部癌疗效可靠,对于DDP耐药的病人仍有一定的有效率,不良反应可以耐受。

Objective To evaluate the efficacy and toxicity of nedaplatine combined with bimonthly 5-FU/LV in the patients with metastasis or recurrent head and neck carcinoma. Methods 28 patients with metastasis or recurrent head and neck carcinoma. The regimen was nedaplatine 1000 mg/m^2 i. v dl ; combined with Leucovorin 200 mg/m^2 i. v, then intravenous bolus of 5-FU 500 mg followed by 48 hour infusion of 5-FU 2. 8 g/m^2 using an ambulatory pump dl, 15. The regimen was given per 4 weeks. All enrolled patients were received at least two cycles of treatment. Results It shows that the complete remission and the partial remission were 47.14% and 46.43% , respectively and the overall response rate of 53.57%. The main adverse reaction was myelosuppression, mueositis and diarrhea. No treatment-related death occurred. Conclution nedaplatine plus bimonthly 5-Fuluorouracil/Leueovorin is effective for metastasis or recurrent head and neck carcinoma, and has a good clinical tolerance.