非小细胞肺癌中甲胎蛋白受体表达的临床意义

Clinical significance of the expression of alpha-fetoprotein receptor in human non small cell lung cancer

目的:研究非小细胞肺癌(NSCLC)中甲胎蛋白受体(alphafetoproteinreceptor,AFPR)表达的临床意义。方法:用免疫组织化学方法分析57例NSCLC组织、癌旁正常肺组织AFPR表达情况。结果:①NSCLC患者肿瘤组织中AFPR阳性率为40.4%(23/57)较正常肺组织15.8%(9/57)明显增高(P<0.05)。②腺癌及腺鳞癌AFPR阳性率59.4%(19/32)显著高于非腺癌16%(4/25)(P<0.05),腺癌AFPR表达与p53呈负相关(P<0.05)。③在不同年龄、不同性别、不同分期、有无淋巴结转移的不同肺癌组织中,AFPR表达阳性率均无显著性差异(P>0.05)。结论:NSCLC组织中AFPR表达明显高于癌旁正常肺组织,AFPR表达与肿瘤病理类型有一定关系。

Objective： To investigate the expression of alpha-fetoprotein receptor （AFPR） in human non-small cell lung cancer （NSCLC） and its clinical meaning. Methods： Immunohistochemical technique was used to analyze the expressions of AFPR in 57 lung cancer tissues and 57 paracancerous normal lung tissues with anti-AFPR antibody. Results： （1） The positive rate of AFPR expression was 40.4% （23/57）in cancer tissues. It was much higher than that in paracancerous normal tissues（15.8%, 9/57, P 〈0.05）. （2）The positive rates of AFPR expression was significantly related to histological classification（P〈0.05）. The AFPR expression in adenocarcinoma and adeno-squamous carcinoma was much higher than that in non adenocarcinoma [59.4% （19/32） vs 16% （4/25）, P〈0.05]. The AFPR expression in adenocarcinoma was negatively correlated with p53 （P〈0.05）. （3）The expression of AFPR was not significantly associated with age, sex, p-TNM stage, and lymph node metastasis of patients with lung adenocarcinoma（P〉0.05）. Conclusion： AFPR expression in NSCLC tissues is much higher than that in paracancerous normal lung tissue. Expression level of AFPR correlates well with histological classification of NSCLC.