胎盘免疫调节因子的实验研究

Experimental Study on Placenta Immunoregulatory Factor

报道了改良的胎盘免疫调节因子（ＰＦ）提取方法，并对制备的ＰＦ理化性质、生物学活性、急性及长期毒性进行了系统的研究。结果表明ＰＦ由３个组分构成，分子量为３８００～５０００，属核酸和多肽类物质，性质稳定。有明显提高机体细胞免疫功能作用。毒性试验证实ＰＦ无毒副作用，长期应用安全。初步临床应用结果提示ＰＦ对鼻咽癌、结核及慢性乙肝患者免疫功能有提高作用。

It was reported that an improved preparative methed of placenta immunoregulatory factor (PF).The physical and chemical property,biological activity,acute and chronic toxicity of prepared PF were studied systematically.The results showed that PF was composed of three compoments,those comerments had approximate molecular weight of about 3800￣5000,belonging to low molecuar weight ribonucleic acid and peptide. Being of a stable property, PF could promoted cell immunolgic function.Toxcity test proved that PF had no side effect and was safe for long time use. Preliminary clinical application results indicated that PF could promote the immunologic function of patients with Nasophasingo cascinoma (NPC),tuberculosis and chronic hepatitis B.