摘要
Objectives-Little epidemiological data is available concerning esophageal adenocarcinomas in France. The aim of this study was to study epidemiological characteristics and management of esophageal adenocarcinoma in a well-defined population. Methods-Data were collected by the Burgundy Digestive Cancer Registry covering a population of 1 052 000, over a 28-year period (1976-2001). Incidence, treatment and stage at diagnosis were noted. Univariate and multivariate analysis of survival was performed. Results-Age standardized incidence rates were 1.60/100,000 in men and 0.15/100,000 in women. The mean increase in incidence rates by 5-year periods were respectively +68.1%(P < 0.001) and +97.4%(P < 0.001). Overall, 69.9%of the cancers were located in the lower third of the esophagus. Surgical resection was performed in 32.1%of patients. Among the surgical patients, the tumor was limited to the esophageal wall in 11.4%, lymph node metastases were present in 18.1%and non-resectable distant metastases in 70.5%. There was no improvement of stage at diagnosis over time. Survival rates were 14.4%at 3 years and 9.2%at 5 years. Five-year survival rates varied from 38.4%for cases limited to the esophageal wall to 1.8%for metastatic and non resectable cases. Stage at diagnosis was the only significant prognostic factor in the multivariate analysis. Conclusion-Esophageal adenocarcinomas are rare cancers characterized by a sharp rise in incidence over the past years in France. Stage at diagnosis and prognosis are worse than reported in hospital statistics.
Objectives - Little cerning esophageal epidemiological data is available conadenocarcinomas in France. The aim of this study was to study epidemiological characteristics and management of esophageal adenocarcinoma in a well- defined population. Methods- Data were collected by the Burgundy Digestive Cancer Registry covering a population of 1 052 000, over a 28-year period （1976 -2001 ） . Incidence, treatment and stage at diagnosis were noted. Univariate and multivariate analysis of survival was performed. Results- Age standardized incidence rates were 1.60/100, 000 in men and 0. 15/100, 000 in women. The mean increase in incidence rates by 5 -year periods were respectively ＋ 68.1% （P〈0.001） and ＋ 97.4% （P〈 0. 001） . Overall, 69.9% of the cancers were located in the lower third of the esophagus performed in 32. 1% of patients. Among the surgical patients, the tumor was limited to the esophageal wall in 11.4%, lymph node metastases were present in 18. 1% and non-resectable distant metastases in 70. 5%.
