血清可溶性转铁蛋白受体在缺铁性贫血诊断中的临床应用

Clinical Application of Serum Souble Transferring Receptor in Diagnosis of Iron Deficiency Anemia

目的测定缺铁性贫血患者可溶性转铁蛋白受体(STfR)、转铁蛋白(TRF)及血清铁蛋白(SF)水平,为缺铁性贫血提供一种实验诊断指标。方法30例正常人,20例单纯缺铁性贫血患者,20例缺铁性贫血合并炎症患者,10例肿瘤合并缺铁性贫血患者,20例非缺铁性贫血患者,分别测定STfR、TRF及SF值,并对结果进行比较。结果缺铁性贫血(IDA)与非缺铁性贫血(ACD)及正常组STfR值差异有显著性(P<0.01),ACD与正常对照组差异无统计学意义(P>0.05);不同类型IDA中,STfR值无统计学意义(P>0.05)。结论STfR是一种特异性,不受干扰因素影响的,可作为缺铁性贫血的实验诊断指标。

Objective Serum transferring receptor （STfR）, transferrin（TRF）, serum ferritin（SF） in iron deficiency anemia （IDA） were investigated to evaluate whether can be used as a diagnostic index. Methods The 30 cases of normal control, 20 patients with simple IDA, 20 patients with inflammation and IDA, and 10 patients with IDA and malignancy, had their STfR, TRF and SF levels measured and compared. Results IDA and ACD showed significant difference in STfR （P〈 0.01 ）, STfR showed no significant difference between ACD and normal control （P 〉 0.05）, between different IDA types the value of STfR showed no significant difference （P 〉 0.0.5）, and the TRF, SF had no significant difference in these measurements. Conclusion STfR is a particular index with no interference factor, can be used in clinical diagnosis of iron deficiency diseases as a routine laboratory test.