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犬尿喹啉酸研究进展 被引量：1

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摘要 犬尿喹啉酸(kynurenic acid,KYNA)是色氨酸(Trp)的代谢产物之一,广泛分布于哺乳动物的体液和中枢神经系统中,能拮抗兴奋性氨基酸(EAA)和烟碱受体,与某些神经系统、眼科、肾脏、免疫性等疾病都有关联。本文就KYNA的生化特性与相关疾病关系作一简单综述。
作者 皮兰敢 王瑞 唐爱国
机构地区 中南大学湘雅二医院检验科
出处 《实用预防医学》 CAS 2006年第4期1092-1094,共3页 Practical Preventive Medicine
关键词 犬尿喹啉酸 色氨酸 N-甲基-D-天冬氨酸受体 α-7-烟碱乙酰胆碱能受体
分类号 R4 [医药卫生—临床医学]
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参考文献21

  • 1Schwarcz R,Pellicciari R.Manipulation of Brain Kynurenines:Glial Targets,Neuronal Effects,and Clinical Opportunities[J].J Pharmacol Exp Ther,2002,303(1):1-10.
  • 2Stone TW.Inhibitors of kynurenine pathway[J].Eur J Med Chem,2000,35(2):179-186.
  • 3Dazzi C,Candiano G,Massazza S,et al.New high-performance liquid chromatographic method for the detection of picolinic acid in biological fluids[J].J Chromatogr B biomed Sci Appl,2001,751 (1):61 -68.
  • 4Zsizsik BK,Hardeland R.Formation of kynurenic and xanthurenic acids from kynurenine and3-hydroxykynurenine in the dinoflagellate Lingulodinium polyedrum:role of a novel,oxidative pathway[J].Comp Biochem Physiol C Toxicol Pharmacol,2002,133 (3):383-392.
  • 5Nemeth H,Robotka H,Kis Z,et al.Kynurenine administered together with probenecid markedly inhibits pentylenetetrazol-induced seizures.An electrophysiological and behavioural study[J].Neuropharmacology,2004,47(6):916-925.
  • 6Hilmas C,Pereira EFR,Alkondon M,et al.The brain metabolite kynurenic acid inhibits α7 nicotinic receptor activity and increases non -α7 nicotinic receptor expression:physiopathological implications[J].J Neueosicence,2001,21(19):7463-7473.
  • 7Robotka H,Nemeth H,Somlai C,et al.Systemically administered glucosamine-kynurenic acid,but not pure kynurenic acid,is effective in decreasing the evoked activity in area CA1 of the rat hippocampus[J].Eur J Pharmacol,2005,513(1-2):75-80.
  • 8Kepplinger B,Baran H,Kainz A,et al.Age-related increase of kynurenic acid in human cerebrospinal fluid-IgG and beta2-microglobulin changes[J].Neurosignals,2005,14(3):126-135.
  • 9Ceresoli-Borroni G,Schwarcz R.Neonatal Asphyxia in Rats:Acute Effects on Cerebral Kynurenine Metabolism[J].Pediatr Res,2001,50(2):231-235.
  • 10Nilsson LK,Linderholm KR,Engberg G,et al.Elevated levels of kynurenic acid in the cerebrospinal fluid of male patients with schizophrenia[J].Schizophr Res,2005,[Epub ahead of print]

二级参考文献10

  • 1[1]Jutta Urenjak,Tihomir P Obrenovitch. Kynurenine 3-Hydroxylase Inhibition in Rats: Effects on Extracellular Kynurenic Acid Concentratin and N-Methyl-D-Aspartate-Induced Deplarisation in the Striatum[J]. J Neurochem, 2000, 75(6): 2427-2433.
  • 2[2]Blandini F, Porter RHP, Greenamyre JT.Glutamate and Parkinson's disease[J]. Mol Neurobiol,1996,12:73-99.
  • 3[3]H Baran, Hainfeller JA, Kepplinger B, et al.Kynurenic acid metabolism in the brain of HIV-1 infected patients[J]. J Neural Transm, 2000,107:1127-1138.
  • 4[4]Klockgether T, Turski L. ()Toward an understandanding of the role glutamate in experimental parkinsonism: agonist-sensitive sites in the basal ganglia[J]. Ann Neurol, 1993,34:585-593.
  • 5[5]Bernard V, Gardiol A, Faucheux B, et al. Expression of glutamate receptors in the human and rat basal ganglia:effect of the dopaminergic denervation on AMPA receptor gene expression in the striatopallidal complex in Parkinson's disease and rat with 6-OHDA lesion[J]. J Comp Neurol,1996,368:553-568.
  • 6[6]Limousin P, Pollak P, Benazzouz A,et al.Effect of parkinsonian signs and syptoms of bilateral subthalamic nucleus stimulation[J]. Lancet,1995, 345: 91-95.
  • 7[7]Miranda AF, Boegman RJ,Beninger RJ. Protection against quinolinic acid mediated excitotoxicity in nigostriatal dopaminergic neurons by endogenous kynurenic acid[J]. Neuroscience,1997,78:967-975.
  • 8[8]Rodriez MC, Obeso JA. Suthalamic nucleus-mediated excitotoxicity in Parkinson′s disease: A target for neuroprotectio[J]. Annals Neurology,1998, 44(Suppl 1):s175-s188.
  • 9[9]Merino M, Vizuete ML, Cano J. The Non-NMDA Glutamate Receptor Antagonists, but Not NMDA Antagonists, Block the Intrastraital Neurotoxic Effect of MPP+[J].J Neurochem, 1999,73(2): 751-757.
  • 10[10]Piallat B, Benazzou A, Benabid AL. Neuroprotective effect of chronic inactivation of the subthalamic nucleus in a rat model of Parkinson's disease. J Neural transm Suppl, 1999, 55: 71-77.

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实用预防医学
2006年 第4期

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