COX-2在B细胞非霍奇金淋巴瘤中的表达及临床意义

The Expression and Clinical Significance of COX-2 in B Cell Non-Hodgkin’s Lymphoma

目的探讨环氧合酶-2(COX-2)在B细胞非霍奇金淋巴瘤(B-NHL)中的表达及临床意义。方法采用免疫组化S-P法检测43例B-NHL和10例良性淋巴结病变组织中COX-2的表达。结果COX-2在B-NHL中的阳性表达率为55·8%(24/43),明显高于对照组,差异具有统计学意义(P<0·05)。COX-2的表达与B-NHL的临床分期和病理组织学等级具有相关性:Ⅲ/Ⅳ期B-NHL患者COX-2蛋白的表达高于Ⅰ/Ⅱ期患者(P<0·05),侵袭性B-NHL患者COX-2蛋白的表达高于惰性组(P<0·01)。COX-2阴性表达患者的5年生存率高于COX-2阳性表达患者(P<0·05)。COX模型显示COX-2是一个独立的不良预后指标。结论COX-2在B-NHL的发生和发展中具有重要作用,并且是一个有用的预后指标。

Objective The purpose of this study was to investigate the expression and clinical significance of cyclooxygenase-2 （COX-2） in B cell Non-Hodgkin＇s lymphoma（B-NHL） .Methods The expression of COX-2 in 43 cases of B-NHL and 10 cases of benign lymph node pathological changes were detected by immunohistochemical streptavidin-biotin peroxidase method, Results The expression rate of COX-2 in B-NHL was 55.8 % （24/43）. Compared with the control group, the difference was statistically significant（ P 〈 0.05 ）. The expression of COX-2 was related to clinical stage and histopathologic grade of B-NHL. The expression of COX-2 in B-NHL patients with stage Ⅲ/Ⅳ was higher than that of patients with stage Ⅰ / Ⅱ （ P 〈 0.05） .The expression of COX-2 in patients with aggressive B-NHL was higher than that of patients with indolent B-NHL （ P 〈 0.01 ）. The 5-year survival rate of patients with COX-2 negative expression was higher than that of COX-2 positive expression （P 〈 0.05）. COX mode showed COX-2 was an independent poor prognosis index. Conclusions COX-2 expression played an important role in the development and progression of B-NHL and was an useful prognosis index.