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肝肠钙粘连蛋白研究进展 被引量：6

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摘要 钙粘连蛋白（cadherin）是Ca^2＋依赖的介导同源细胞间相互粘附的多基因家族。目前已经发现100多个钙粘连蛋白家族成员，根据它们的结构和功能特点分为经典钙粘连蛋白（classic cadherin）、桥粒钙粘连蛋白（desmosomal cadherin）、原钙粘连蛋白（protocadherin）以及其他类型钙粘连蛋白。大部分钙粘连蛋白家族成员有着相似的结构及生物学功能，它们不仅在细胞粘附，细胞识别以及调控组织器官形态发生中起重要作用，而且参与介导细胞信号转导甚至神经传导等。如果钙粘连蛋白的活动异常，细胞之间的粘附功能会出现紊乱，导致组织细胞结构改变和功能障碍。研究表明，有些钙粘连蛋白的结构和功能异常与肿瘤的侵袭转移密切相关。
作者 王苒 刘小莉 Gessner R 王立东
机构地区 河南省食管癌重点开放实验室 德国Humboldt大学Charite医学院
出处 《肿瘤基础与临床》 2006年第4期348-349,共2页 journal of basic and clinical oncology
基金 河南省医学科技攻关项目(编号:20058)
关键词 LI-CADHERIN 钙粘连蛋白 肿瘤侵袭和转移
分类号 R730.231 [医药卫生—肿瘤] R329.27 [医药卫生—人体解剖和组织胚胎学]
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参考文献17

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二级参考文献21

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共引文献16

同被引文献59

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引证文献6

二级引证文献7

肿瘤基础与临床
2006年 第4期

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