摘要
硫唑嘌呤(AZA)/6-巯嘌呤(6-MP)是治疗炎性肠病(IBD)的重要药物,治疗过程中最严重的不良反应是骨髓抑制。硫嘌呤甲基转移酶(TPMT)是6-MP代谢的关键酶,本文综述IBD患者用AZA/6-MP治疗前检测TPMT的临床意义。
Azathioprine （AZA） and 6-mercaptopurine （6-MP） have a well-established effect as an immunosuppressive agent for inflammatory bowel disease （IBD）, Myelosuppression is the most serious side effect during treatment. Thiopurine methyltransferase（TPMT） plays an important role in the metabolism of 6-MP. This article reviews the literature on the role of TPMT measurement prior to treatment of IBD with AZA/6-MP.
出处
《基础医学与临床》
CSCD
北大核心
2006年第7期776-780,共5页
Basic and Clinical Medicine
关键词
炎性肠病
硫唑嘌呤
6-巯嘌呤
硫嘌呤甲基转移酶
inflammatory bowel disease
azathioprine
6-mercaptopurine
thioprine methyltransferase
