摘要
通过静电纺丝技术可以仿生天然细胞外基质(ECM)的结构特点和生物学功能,构建具有纳米纤维结构的细胞生长支架,为引导组织的再生与修复提供理想的细胞生长微环境。本文介绍了静电纺丝技术的基本原理、影响支架微观结构的主要因素、以及支架在介导细胞生长中的作用和一些应用探索;重点阐述了近几年来静电纺丝技术在促进细胞黏附、增殖以及支持干细胞生长和分化等方面的研究进展,并对今后的研究提出了展望和思考。
Electrospinning is a new technique used to fabricate nanofibrous scaffold for guidance of tissue repair and regeneration. Electrospun scaffold simulates the structure and biological function of native extracellular matrix (ECM) and may provide an ideal engineered microenvironment for cell growth. In this paper, the principle of electrospinning technique and important processing parameters were briefly introduced. Investigations and developments in recent years regarding to the applications of tissue repair and regeneration were reviewed, several focusing issues of electrospinning were addressed as well. The significance and problems unresolved were discussed.
出处
《基础医学与临床》
CSCD
北大核心
2006年第7期689-693,共5页
Basic and Clinical Medicine
基金
国家自然科学基金(90306004)
国家纳米中心基金
关键词
纳米技术
纳米纤维结构支架
再生与修复
静电纺丝
nanotechnology
nanofibrious scaffold
regeneration and repair
electrospinning