超声造影剂联合高强度聚焦超声损伤兔肝VX2移植瘤的可行性研究

Feasibility study of high intensity focused ultrasound combining with ultrasound contrast agent to damage hepatic VX2 tumors in rabbits

目的研究超声造影剂作为一种增效剂,增强高强度聚焦超声的生物学效应,损伤兔肝VX2移植瘤的可行性。方法30只荷瘤兔随机分为二组,单纯高强度聚焦超声辐照组和联合辐照组,超声造影剂剂量为0.05ml/kg。结果联合辐照组的辐照时间明显缩短(P<0.05),损伤肿瘤体积大大增加(P<0.01),损伤效率高于单纯高强度聚焦超声辐照组(P<0.01)。结论超声造影剂可以提高高强度聚焦超声损伤效率,靶区组织的声学特性、组织结构或者功能状态可以影响高强度聚焦超声治疗剂量。

Objective To assess the feasibility of ultrasound microbubble contrast agent combining with high intensity focused ultrasound to treat hepatic VX2 tumors in rabbits. Methods Thirty rabbits borne VX2 tumors were randomly averagely assigned into two groups. One group accepted purely high intensity focused ultrasound （HIFU） irradiation, and the other group accepted treatment by HIFU combined with ultrasound contrast agent. Results Duration of purely high intensity focused ultrasound therapy tumors was much longer than that of enhanced high intensity focused ultrasound group, but smaller damaged volumes. Conclusion It was feasible to enhance HIFU therapy with microbubble contrast agent. The ener- gy efficiency factor （EEF） can be changed and decreased by actively changing tissue structure and its function.