子宫肌瘤剔除术后口服米非司酮预防肌瘤再发的临床观察

A clinical study of mifepristone preventing relapse of the post hysteromyomectomy

目的：探讨子宫肌瘤剔除术后,服用米非司酮（Mifepristone）对预防肌瘤再发的临床效果.方法：将年龄在30～35岁之间,生育一胎,多发肌壁间肌瘤,子宫≤14孕周的100例子宫肌瘤剔除术后的病例分成两组,术后服用米非司酮的50例患者为研究组,不服用米非司酮及相关药物的50例患者为对照组.研究组术后14d开始每晚空腹服用米非司酮10mg,1次/d,连服3个月.3个月后观察,周期为3a.结果：3a后肌瘤再发率不同,研究组再发3例（6%）,对照组再发10例（20%）,P〈0.05,差异有显著性.结论：小剂量米非司酮用于预防子宫肌瘤剔除术后的肌瘤再发安全、有效.

Objective： To investigate the effects of mifepristone preventing relapse of the hysteromyomectomy. Methods： 100 cases were carried out hysteromyomectomy from January of 1999 to March of 2002. They were 30～35 years old, had one child and have intramural myoma and the size of their uterine no more than 12 weeks of pregnancy. 50 cases took mifepristone 10mg once a day lasting for 3 months begin with 14th day after operation and considered as a researching group. 50 cases who had not took mifepristone considered as a comparing group. After three months begin to observed lasting three years. Results： After three years, the rate of relapse in two groups was observed. There were very different. For the researching group, three cases relapsed myoma （6%）. As to the comparing group, ten cases relapsed myoma（20%）, P〈0.05. The difference was statistically significant. Conclusion： The small dose mifepristone is safe and effective drug in preventing relapse of the post hysteromyyomectomy.