对诊断PADAM的血清游离睾酮界限值的初探

Study on the threshold value of serum free testosterone for the diagnosis of PADAM

目的探寻诊断中老年男子部分雄激素缺乏综合征(PADAM)血清游离睾酮(FT)的界限值。方法根据60例45岁以上健康男性完成伊斯坦布尔症状量表(ISS)与视听性刺激(AVSS)时阴茎勃起监测结果进行分组,计算AVSS勃起功能正常组推算的游离睾酮(CFT)值的参考范围。结果AVSS勃起功能正常组CFT的中位数为0．37(0．20～0．52)nmol/L,异常组的中位数为0．25(0．12～0．40)nmol/L,z=2．25,P＜0．05,差别有显著性意义。两组性功能症状的差别也有极显著性意义(P＜0．01)。CFT的界限值是0．20nmol/L。结论研究用ISS和AVSS勃起功能正常对象的血清FT值,可为诊断PADAM建立界限值。

Objective To find out the threshold value of serum free testosterone for the diagnosis of the partial androgen deficiency in the aging male （PADAM）. Methods 60 healthy males over 45 years of age who have finished the Istanbul syndrome score were enrolled in the study. According to the results of the penis erection value in AVSS, they were divided into two groups - normal group and abnormal group. The reference scopes of the calculated free testosterone （CFT） in normal group were calculated. Results The results of CFT were 0.37 （0.20～0.52） nmol/L in normal group and 0.25 （0.12～0.40） nmol/L in abnormal group, and the difference of CFT was remarkably signifi- cant （z=2.25, P 〈 0.05）. The difference of the sexual function syndrome in both groups was also remarkably significant （P〈0.01）. The threshold value of CFT was 0.20nmol/L. Conclusion Through the serum FT value of male with normal erection function in AVSS, the threshold value could be established for the diagnosis of PADAM.