不同工艺制备的固体脂质纳米粒系统性能比较研究

A Comparative Study on Properties of SLN Systems Prepared by Different Procedures

目的:比较不同工艺制备的固体脂质纳米粒系统性能。方法:分别采用长时间高剪切法、长时间探头超声法、单次高剪切超声法和改进的高剪切超声法制备固体脂质纳米粒混悬液,应用激光粒度仪分析仪测定纳米粒粒径及其分布特征,据此评价4种方法制备的固体脂质纳米粒系统性能。结果:与其他3种制备方法比较,改进的高剪切超声法制备的固体脂质纳米粒混悬液粒径分布窄,且呈单模分布,平均粒径约100 nm,具良好的贮存稳定性,4℃下可稳定放置达半年。结论:改进的高剪切超声法可制备出性能优良的稳定的固体脂质纳米粒系统。

Objective： To compare the properties of solid lipid nanoparticles （SLN） systems prepared by different procedures. Methods： The four methods of long time high shear, long time probe ultrasound, once high shear and ultrasound and modified high shear and ultrasound were used respectively to prepare SLN suspensions. Then the properties of particle distribution and particle size of the SLN prepared by the four methods were measured by laser diffraction, which were used to assess their properties. Results： Compared with by the other methods, the SLN suspension with narrow and mono-module particle distribution and mean particle size of about 100 nm was prepared by the modified high shear and ultrasound method. It was stored stably up to a half year at 4℃. Conclusion： The modified method could be used to prepare the stable SLN system with excellent property.