冠心病患者血浆脂联素水平的研究

Study on the Plasma Adiponectin Concentration in Patient with Coronary Heart Disease

目的:研究血浆脂联素水平与冠心病的相关性。方法:87例冠心病患者和73例对照组常规测量体重、身高和血压,计算体重指数,抽取空腹静脉血检测血糖、甘油三酯、总胆固醇、低密度脂蛋白、高密度脂蛋白及血浆脂联素水平。结果:两组BMI、DBP、T-CHOL、LDL-C比较均无差异(P>0.05)。冠心病组SBP、FPG、TG显著高于对照组SBP(P<0.01);而冠心病组HDL-C显著低于对照组(P<0.01)。冠心病患者血浆脂联素水平低于对照组(5.01ug/mLvs.7.86ug/mL,P<0.01)。Logistic回归分析提示血浆脂联素水平与冠心病的发病呈负相关(OR:0.868,95.0%C.I:0.785～0.959,P<0.01)。结论:血浆脂联素可能是冠心病发病的一个保护因素。

Objectives： To study the correlation of plasma adiponectin concentration and coronary heart disease （CHD）. Methods： Body weight, height, blood pressure and body mass index （BMI） were measured routinely in 87 CHD patients and 73 control subjects. FPG,TG,T-CHOL,LDL-C,HDL-C of fasting blood samples were examined by automatic biochemistry analyzer. Plasma concentrations of adiponectin were detected by enzyme-linked immunosorbentassay （ELISA）. Results： No statistical differences was found in the levels of BMI,DBP,T-chol and LDL-C between two groups （P 〉 0.05）. The levels of SBP,FPG and TG in CHD patients were significant higher than those in control subjects （P 〈 0.01）,but the level of HDL-C was significant lower than that in control subjects （P 〈 0.01）. The plasma adiponectin concentration in CHD patients was significant lower than that in control subjects （5.01 ug/mL vs. 7.86 ug/mL,P 〈 0.01）. The results of Logistic regression analyses showed that plasma adiponectin concentration was negatively correlated with CHD（OR： 0.868, 95.0% C.I： 0.785-0.959, P 〈 0.01）. Condusion. Adiponectin was a possible protective factor for CHD.